Nanometer Tungsten Sulfide Will Treat Cancer Cells In The Future
Photothermal therapy utilizes with high light heat conversion efficiency, inject it into the human body, target recognition technique is used to aggregate near the tumor tissue.
The method of converting light energy into heat energy to kill cancer cells under the irradiation of external light source is a kind of cancer treatment method with great expectation by human beings.
In the process of photothermal therapy, the selection of photothermal agents is a key link. These therapeutic agents can effectively convert laser energy into heat energy, thus enhancing the heating efficiency of laser. In order to achieve effective and selective photothermal therapy, photothermal agents must meet several conditions: It can absorb and transform laser energy effectively; A solvent that can be dissolved in a biologically friendly solvent, ensure that the treatment agent enters the tumor tissue smoothly; The surface of particles is easy to be functionalized, which is conducive to the cooperation with other methods such as targeted therapy; Low toxicity of the material itself.
Graphene has excellent biocompatibility, stability, low cytotoxicity and other advantages, the band gap of graphene is zero, the fluorescence intensity of quantum dots is weak, the quantum yield is low, and it is not a perfect photothermal agent. When graphene is abandoned, transition metal two dimensional sulfides have attracted much interest, nano tungsten sulfide (molybdenum) is a sandwich structure consisting of hexagonal metal atoms sandwiched between two layers of sulfur elements, the band gap of the two-dimensional structure is 2.0eV (1.9eV), it has better light conversion and absorption capacity, tungsten itself is an excellent X- ray absorbing material, it has a wide range of applications in the field of hospital testing imaging equipment, therefore, in the process of photothermal therapy, tungsten sulfide can be used for contrast imaging, and can be used for the treatment of operation, can achieve dynamic tracking, diagnosis and treatment integration.
Uniform size tungsten disulfide nanosheets were obtained by intercalation of lithium ions, the surface modification of poly (ethylene glycol) polymer makes it have better water solubility and biocompatibility, tungsten sulfide nanomaterials have good optical absorption properties in the near infrared region. The sulfur nanoparticles were injected into the mice through the caudal vein, and the tumor was enriched by the high permeability and retention effect (EPR effect) of the tumor. Because tungsten can absorb X- rays, it is the first time to achieve very good tumor CT imaging in animal models. At the same time, based on the near-infrared absorption property of tungsten sulfide nanomaterials, it can be used for photoacoustic imaging of tumors. Under the near-infrared laser irradiation, all the tumors were completely killed and reached the goal of complete cure.
Research shows that nano tungsten sulfide treatment agent in the future will likely be large-scale clinical application in cancer therapy, as a tool for human tumor sniper, which is mainly due to nano material not only has good absorption of tungsten sulfide and light conversion properties, but also has low toxicity, and can be modified through molecular and simple cells compatible.
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