Hyperlipidemia is one of the causes of hyperlipidemic acute pancreatitis, at the same time, hyperlipidemia is also the manifestation of metabolic disorder of acute pancreatitis.
Patients with acute pancreatitis due to impaired pancreatic function, fat metabolism disorders, during the course of the disease, blood lipids rise dramatically, greatly increasing the amount of fat in the blood, the appearance of the patient's serum is extremely cloudy with milk, which is commonly referred to as severe chylous blood.
Chylous blood interferes with colorimetric and turbidimetric tests of biochemical tests, leading to the fact that patients with acute pancreatitis are not diagnosed in time. And acute pancreatitis is an acute abdomen, the condition is critical, and even severe shock or death, the clinical need to grasp the relevant inspection data, in order to timely diagnosis.
Some scholars believe that the phosphorus magnesium tungstate precipitation method can effectively get rid of chylemia interference on the detection of acute pancreatitis, chylemia contains glycerin three greases, the principle of magnesium phosphosilicate as precipitant to detect HDL-C is that the polyanion interacts with divalent metal ions, an insoluble complex with apolipoprotein B in serum. Therefore, magnesium phosphotungstate can selectively precipitate apolipoprotein containing apolipoprotein B, VLDL, low density lipoprotein and lipoprotein, high-density lipoprotein (HDL), which contains only apolipoprotein B in serum lipoproteins, can be detected individually.
Through comparative test, scholars believe that the detection results of phosphorus magnesium tungstate precipitation method is accurate, this acute pancreatitis test can effectively eliminate the severe chylous condition in the specimens of patients with acute pancreatitis, conducive to timely diagnosis and treatment of patients, biochemical and phosphorus magnesium tungstate precipitation method for the vast majority of interference will not occur. The method has the advantages of simple operation, quick operation, obvious precipitating effect, convenient reagent source, no special equipment and low cost, suitable for all hospitals in the laboratory, is the ideal specimens of HLAP specimens and other chyme specimens of biochemical testing pre-treatment methods.
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